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https://hdl.handle.net/2440/100007
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Type: | Journal article |
Title: | Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation |
Author: | Tarulli, G. Laven-Law, G. Shakya, R. Tilley, W. Hickey, T. |
Citation: | Journal of Mammary Gland Biology and Neoplasia, 2015; 20(1-2):75-91 |
Publisher: | Springer New York |
Issue Date: | 2015 |
ISSN: | 1083-3021 1573-7039 |
Statement of Responsibility: | Gerard A. Tarulli, Geraldine Laven-Law, Reshma Shakya, Wayne D. Tilley, Theresa E. Hickey |
Abstract: | The hormone-sensing mammary epithelial cell (HS-MEC-expressing oestrogen receptor-alpha (ERα) and progesterone receptor (PGR)) is often represented as being terminally differentiated and lacking significant progenitor activity after puberty. Therefore while able to profoundly influence the proliferation and function of other MEC populations, HS-MECs are purported not to respond to sex hormone signals by engaging in significant cell proliferation during adulthood. This is a convenient and practical simplification that overshadows the sublime, and potentially critical, phenotypic plasticity found within the adult HS-MEC population. This concept is exemplified by the large proportion (~80 %) of human breast cancers expressing PGR and/or ERα, demonstrating that HS-MECs clearly proliferate in the context of breast cancer. Understanding how HS-MEC proliferation and differentiation is driven could be key to unraveling the mechanisms behind uncontrolled HS-MEC proliferation associated with ERα- and/or PGR-positive breast cancers. Herein we review evidence for the existence of a HS-MEC progenitor and the emerging plasticity of the HS-MEC population in general. This is followed by an analysis of hormones other than oestrogen and progesterone that are able to influence HS-MEC proliferation and differentiation: androgens, prolactin and transforming growth factor-beta1. |
Keywords: | Endocrine hormones; Hormone-sensing cells; Luminal progenitors; Androgen; Prolactin |
Description: | Published online: 21 September 2015 |
Rights: | © Springer Science+Business Media New York 2015 |
DOI: | 10.1007/s10911-015-9344-1 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1008349 http://purl.org/au-research/grants/nhmrc/1084416 |
Published version: | http://dx.doi.org/10.1007/s10911-015-9344-1 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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