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Type: Journal article
Title: Mechano-reciprocity is maintained between physiological boundaries by tuning signal flux through the Rho-associated protein kinase
Author: Boyle, S.
Samuel, M.
Citation: Small GTPases, 2016; 7(3):139-146
Publisher: Taylor & Francis
Issue Date: 2016
ISSN: 2154-1248
Statement of
Sarah T. Boyle and Michael S. Samuel
Abstract: The mechanical properties of the ECM strongly influence the behavior of all cell types within a given tissue. Increased matrix tension promotes epithelial cell proliferation by engaging mitogenic mechanotransduction signaling including the Salvador/Warts/Hippo, PI 3-kinase, Rho, Wnt and MAP kinase pathways. The Rho signaling pathways in particular are capable of increasing intra-cellular tension by elevating the production and contractility of the actomyosin cytoskeleton, which counteracts tension changes within the matrix in a process termed mechano-reciprocity. We have discovered that Rho-ROCK signaling increases the production of ECM through paracrine signaling between the epithelium and fibroblasts and also the remodeling of the ECM by regulating focal adhesion dynamics in fibroblasts. These two phenomena together cause increased ECM tension. Enhanced mechano-reciprocity results in ever-increasing intra- and extra-cellular tension in a vicious cycle that promotes cell proliferation and tumor progression. These insights reveal that inhibiting mechano-reciprocity, reducing ECM tension and targeting cancer-associated fibroblasts in a coordinated fashion has potential as cancer therapy.
Keywords: 14-3-3ζ; cancer; extra-cellular matrix; fibroblasts; mechanoreciprocity; mechanotransduction; MYPT; Rho; ROCK; wound healing
Description: Published online: 11 May 2016
Rights: © 2016 Taylor & Francis
RMID: 0030047793
DOI: 10.1080/21541248.2016.1173771
Appears in Collections:Pathology publications

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