Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/100172
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dc.contributor.authorSandow, J.en
dc.contributor.authorDorstyn, L.en
dc.contributor.authorO'Reilly, L.en
dc.contributor.authorTailler, M.en
dc.contributor.authorKumar, S.en
dc.contributor.authorStrasser, A.en
dc.contributor.authorEkert, P.en
dc.date.issued2014en
dc.identifier.citationCell Death and Differentiation, 2014; 21(3):475-480en
dc.identifier.issn1350-9047en
dc.identifier.issn1476-5403en
dc.identifier.urihttp://hdl.handle.net/2440/100172-
dc.description.abstractA recent report claimed that endoplasmic reticulum (ER) stress activates the ER trans-membrane receptor IRE1α, leading to increased caspase-2 levels via degradation of microRNAs, and consequently induction of apoptosis. This observation casts caspase-2 into a central role in the apoptosis triggered by ER stress. We have used multiple cell types from caspase-2-deficient mice to test this hypothesis but failed to find significant impact of loss of caspase-2 on ER-stress-induced apoptosis. Moreover, we did not observe increased expression of caspase-2 protein in response to ER stress. Our data strongly argue against a critical role for caspase-2 in ER-stress-induced apoptosis.en
dc.description.statementofresponsibilityJJ Sandow, L Dorstyn, LA O, Reilly, M Tailler, S Kumar, A Strasser, and PG Ekerten
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2014 Macmillan Publishers Limited All rights reserveden
dc.subjectCaspase-2; ER stress; apoptosisen
dc.titleER stress does not cause upregulation and activation of caspase-2 to initiate apoptosisen
dc.typeJournal articleen
dc.identifier.rmid0030022846en
dc.identifier.doi10.1038/cdd.2013.168en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1022916en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1021456en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1043057en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1009145en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1016701en
dc.identifier.pubid108292-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidKumar, S. [0000-0001-7126-9814]en
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