Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/101391
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | High mitochondrial accumulation of new gadolinium(III) agents within tumour cells |
| Author: | Morrison, D. Aitken, J. De Jonge, M. Ioppolo, J. Harris, H. Rendina, L. |
| Citation: | Chemical Communications, 2014; 50(18):2252-2254 |
| Publisher: | Royal Society of Chemistry |
| Issue Date: | 2014 |
| ISSN: | 1359-7345 1364-548X |
| Statement of Responsibility: | Daniel E. Morrison, Jade B. Aitken, Martin D. de Jonge, Joseph A. Ioppolo, Hugh H. Harris and Louis M. Rendina |
| Abstract: | The first bifunctional GdIII complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 1010 Gd atoms per tumour cell. |
| Keywords: | Cell Line, Tumor Mitochondria Humans Neoplasms Gadolinium Organometallic Compounds Antineoplastic Agents Drug Screening Assays, Antitumor Molecular Structure Structure-Activity Relationship Dose-Response Relationship, Drug Drug Design |
| Rights: | This journal is © The Royal Society of Chemistry 2014 |
| DOI: | 10.1039/c3cc46903d |
| Published version: | http://dx.doi.org/10.1039/c3cc46903d |
| Appears in Collections: | Aurora harvest 7 Chemistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.