Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/101545
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Type: Journal article
Title: Autophagy regulates the survival of cells with chromosomal instability
Author: Liu, D.
Shaukat, Z.
Xu, T.
Denton, D.
Saint, R.
Gregory, S.
Citation: Oncotarget, 2016; 7(39):63913-63923
Publisher: Impact Journals
Issue Date: 2016
ISSN: 1949-2553
1949-2553
Statement of
Responsibility: 
Dawei Liu, Zeeshan Shaukat, Tianqi Xu, Donna Denton, Robert Saint, Stephen Gregory
Abstract: Chromosomal instability (CIN) refers to genomic instability in which cells have gained or lost chromosomes or chromosomal fragments. A high level of CIN is common in solid tumours and is associated with cancer drug resistance and poor prognosis. The impact of CIN-induced stress and the resulting cellular responses are only just beginning to emerge. Using proliferating tissue in Drosophila as a model, we found that autophagy is activated in CIN cells and is necessary for their survival. Specifically, increasing the removal of defective mitochondria by mitophagy is able to lower levels of reactive oxygen species and the resultant cellular damage that is normally seen in CIN cells. In response to DNA damage, CIN is increased in a positive feedback loop, and we found that increasing autophagy by Tor depletion could decrease the level of CIN in proliferating cells. These findings underline the importance of autophagy control in the development of CIN tumours.
Keywords: chromosomal instability; autophagy; mitophagy; parkin; drosophila
Rights: © Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
RMID: 0030054040
DOI: 10.18632/oncotarget.11736
Grant ID: http://purl.org/au-research/grants/nhmrc/1087308
Appears in Collections:Genetics publications

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