Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/101832
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorXu, T.en
dc.contributor.authorNicolson, S.en
dc.contributor.authorDenton, D.en
dc.contributor.authorKumar, S.en
dc.date.issued2015en
dc.identifier.citationCell Death and Differentiation, 2015; 22(11):1792-1802en
dc.identifier.issn1350-9047en
dc.identifier.issn1476-5403en
dc.identifier.urihttp://hdl.handle.net/2440/101832-
dc.descriptionPublished online 17 April 2015en
dc.description.abstractAlthough most programmed cell death (PCD) during animal development occurs by caspase-dependent apoptosis, autophagy-dependent cell death is also important in specific contexts. In previous studies, we established that PCD of the obsolete Drosophila larval midgut tissue is dependent on autophagy and can occur in the absence of the main components of the apoptotic pathway. As autophagy is primarily a survival mechanism in response to stress such as starvation, it is currently unclear if the regulation and mechanism of autophagy as a pro-death pathway is distinct to that as pro-survival. To establish the requirement of the components of the autophagy pathway during cell death, we examined the effect of systematically knocking down components of the autophagy machinery on autophagy induction and timing of midgut PCD. We found that there is a distinct requirement of the individual components of the autophagy pathway in a pro-death context. Furthermore, we show that TORC1 is upstream of autophagy induction in the midgut indicating that while the machinery may be distinct the activation may occur similarly in PCD and during starvation-induced autophagy signalling. Our data reveal that while autophagy initiation occurs similarly in different cellular contexts, there is a tissue/function-specific requirement for the components of the autophagic machinery.en
dc.description.statementofresponsibilityT Xu, S Nicolson, D Denton and S Kumaren
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2015 Macmillan Publishers Limited All rights reserved.en
dc.subjectAtg, autophagy-related; PCD, programmed cell death; PI3K, phosphatidylinositol 3-kinase; RPF, relative to puparium formation; TOR, target of rapamycinen
dc.titleDistinct requirements of Autophagy-related genes in programmed cell deathen
dc.typeJournal articleen
dc.identifier.rmid0030051065en
dc.identifier.doi10.1038/cdd.2015.28en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1041807en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1002863en
dc.identifier.pubid258654-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidKumar, S. [0000-0001-7126-9814]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.