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https://hdl.handle.net/2440/101833
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Type: | Journal article |
Title: | Autophagy in malignant transformation and cancer progression |
Author: | Galluzzi, L. Pietrocola, F. Bravo-San Pedro, J. Amaravadi, R. Baehrecke, E. Cecconi, F. Codogno, P. Debnath, J. Gewirtz, D. Karantza, V. Kimmelman, A. Kumar, S. Levine, B. Maiuri, M. Martin, S. Penninger, J. Piacentini, M. Rubinsztein, D. Simon, H. Simonsen, A. et al. |
Citation: | The EMBO Journal, 2015; 34(7):856-880 |
Publisher: | EMBO Press |
Issue Date: | 2015 |
ISSN: | 0261-4189 1460-2075 |
Statement of Responsibility: | Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo-San Pedro, Ravi K Amaravadi, Eric H Baehrecke, Francesco Cecconi, Patrice Codogno, Jayanta Debnath, David A Gewirtz, Vassiliki Karantza, Alec Kimmelman, Sharad Kumar, Beth Levine, Maria Chiara Maiuri, Seamus J Martin, Josef Penninger, Mauro Piacentini, David C Rubinsztein, Hans-Uwe Simon, Anne Simonsen, Andrew M Thorburn, Guillermo Velasco, Kevin M Ryan and Guido Kroemer |
Abstract: | Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy. |
Keywords: | adaptive stress responses; Beclin 1; inflammation; KRAS; mitophagy |
Description: | Published online 23 February 2015 |
Rights: | © 2015 The Authors |
DOI: | 10.15252/embj.201490784 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1041807 http://purl.org/au-research/grants/nhmrc/1002863 |
Published version: | http://dx.doi.org/10.15252/embj.201490784 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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