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dc.contributor.authorAllen, W.en
dc.contributor.authorChin, L.en
dc.contributor.authorWijesinghe, P.en
dc.contributor.authorKirk, R.en
dc.contributor.authorLatham, B.en
dc.contributor.authorSampson, D.en
dc.contributor.authorSaunders, C.en
dc.contributor.authorKennedy, B.en
dc.identifier.citationBiomedical Optics Express, 2016; 7(10):4139-4153en
dc.descriptionPublished 19 Sep 2016en
dc.description.abstractIncomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.en
dc.description.statementofresponsibilityWes M. Allen, Lixin Chin, Philip Wijesinghe, Rodney W. Kirk, Bruce Latham, David D. Sampson, Christobel M. Saunders, and Brendan F. Kennedyen
dc.publisherOptical Society of Americaen
dc.rights©2016 Optical Society of America. Open Access - CC BY license.en
dc.subject(110.4500) Optical coherence tomography; (170.0170) Medical optics and biotechnologyen
dc.titleWide-field optical coherence microelastography for intraoperative assessment of human breast cancer marginsen
dc.typeJournal articleen
pubs.library.collectionIPAS publicationsen
Appears in Collections:IPAS publications

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