Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/103709
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: From the mine to cancer therapy: natural and biodegradable theranostic silicon nanocarriers from diatoms for sustained delivery of chemotherapeutics
Author: Maher, S.
Kumeria, T.
Wang, Y.
Kaur, G.
Fathalla, D.
Fetih, G.
Santos, A.
Habib, F.
Evdokiou, A.
Losic, D.
Citation: Advanced Healthcare Materials, 2016; 5(20):2667-2678
Publisher: Wiley-Blackwell
Issue Date: 2016
ISSN: 2192-2640
2192-2659
Statement of
Responsibility: 
Shaheer Maher, Tushar Kumeria, Ye Wang, Gagandeep Kaur, Dina Fathalla, Gihan Fetih, Abel Santos, Fawzia Habib, Andreas Evdokiou, Dusan Losic
Abstract: Drug delivery using synthetic nanoparticles including porous silicon has been extensively used to overcome the limitations of chemotherapy. However, their synthesis has many challenges such as lack of scalability, high cost, and the use of toxic materials with concerning environmental impact. Nanoscale materials obtained from natural resources are an attractive option to address some of these disadvantages. In this paper, a new mesoporous biodegradable silicon nanoparticle (SiNP) drug carrier obtained from natural diatom silica mineral available from the mining industry is presented. Diatom silica structures are mechanically fragmented and converted into SiNPs by simple and scalable magnesiothermic reduction process. Results show that SiNPs have many desirable properties including high surface area, high drug loading capacity, strong luminescence, biodegradability, and no cytotoxicity. The in-vitro release results from SiNPs loaded with anticancer drugs (doxorubicin) demonstrate a pH-dependent and sustained drug release with enhanced cytotoxicity against cancer cells. The cells study using doxorubicin loaded SiNPs shows a significantly enhanced cytotoxicity against cancer cells compared with free drug, suggesting their considerable potential as theranostic nanocarriers for chemotherapy. Their low-cost manufacturing using abundant natural materials and outstanding chemotherapeutic performance has made them as a promising alternative to synthetic nanoparticles for drug delivery applications.
Keywords: Diatoms; doxorubicin; luminescence; porous silicon; sustained release
Rights: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0030054113
DOI: 10.1002/adhm.201600688
Grant ID: http://purl.org/au-research/grants/arc/DP120101680
http://purl.org/au-research/grants/arc/FT110100711
http://purl.org/au-research/grants/arc/DE140100549
Appears in Collections:Chemical Engineering publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.