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https://hdl.handle.net/2440/10467
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Type: | Journal article |
Title: | Perductal electrolytic ablation of the porcine pancreas |
Author: | Morrison, C. Court, F. Wemyss-Holden, S. Teague, B. Burrell, A. Texler, M. Metcalfe, M. Dennison, A. Maddern, G. |
Citation: | Surgical Endoscopy: surgical and interventional techniques, 2004; 18(10):1435-1441 |
Publisher: | Springer |
Issue Date: | 2004 |
ISSN: | 0930-2794 1432-2218 |
Statement of Responsibility: | C.P. Morrison, F.G. Court, S.A. Wemyss-Holden, B. D. Teague, A. Burrell, M. Texler, M.S. Metcalfe, A.R. Dennison and G.J. Maddern |
Abstract: | Background: Pancreatic cancer has a dismal prognosis. Few patients are suitable for surgical resection, leaving the majority requiring symptom palliation. Current palliative techniques such as surgical bypass and endoscopic retrograde cholangiopancreatography (ERCP) are imperfect. A novel palliative therapy combining the symptom control of surgical bypass with the minimally invasive nature of ERCP is required. Methods: Perductal electrolytic ablation of pancreatic tissue, in a porcine model, was performed. There were two survival groups of 2 weeks (n = 4) and 8 weeks (n = 4). Postoperatively, serum biochemistry, amylase and C-reactive protein (CRP) were assessed. Histological examination of the pancreas, lungs, and kidneys was performed to determine the presence of acute pancreatitis or systemic inflammatory response. Results: An immediate transient increase in both amylase and CRP was seen. Although pancreatic histology demonstrated localised necrosis at the electrolytic site at 2 weeks, there was no evidence of generalized pancreatitis or a systemic inflammatory response at either 2 or 8 weeks. Conclusions: This study suggests that, although there is localized pancreatic necrosis and transient hyperamylasemia, perductal pancreatic electrolytic ablation is safe, with neither generalized pancreatitis nor a systemic inflammatory response, in the medium and long term. Although performed in normal porcine pancreas, because of the absence of a large-animal model of pancreatic cancer, this study suggests that electrolytic pancreatic ablation is safe. This technique may have a role in the palliation of pancreatic cancer, especially if delivered via a minimally, invasive approach, and warrants further investigation. |
Keywords: | Pancreas Electrolysis Local ablation Palliation Experimental studies |
Description: | The original publication is available at www.springerlink.com |
DOI: | 10.1007/s00464-003-9270-y |
Published version: | http://dx.doi.org/10.1007/s00464-003-9270-y |
Appears in Collections: | Aurora harvest 2 Surgery publications |
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