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https://hdl.handle.net/2440/104688
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Type: | Journal article |
Title: | Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
Author: | Lane, J.M. Liang, J. Vlasac, I. Anderson, S.G. Bechtold, D.A. Bowden, J. Emsley, R. Gill, S. Little, M.A. Luik, A.I. Loudon, A. Scheer, F.A.J.L. Purcell, S.M. Kyle, S.D. Lawlor, D.A. Zhu, X. Redline, S. Ray, D.W. Rutter, M.K. Saxena, R. |
Citation: | Nature Genetics, 2017; 49(2):274-281 |
Publisher: | NATURE PORTFOLIO |
Issue Date: | 2017 |
ISSN: | 1061-4036 1546-1718 |
Statement of Responsibility: | Jacqueline M Lane, Jingjing Liang, Irma Vlasac, Simon G Anderson, David A Bechtold, Jack Bowden, Richard Emsley, Shubhroz Gill, Max A Little, Annemarie I Luik, Andrew Loudon, Frank A J L Scheer, Shaun M Purcell, Simon D Kyle, Deborah A Lawlor, Xiaofeng Zhu, Susan Redline, David W Ray, Martin K Rutter, Richa Saxena |
Abstract: | Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders and all-cause mortality¹’², affect 25–30% of adults worldwide³. Although environmental factors contribute substantially to self-reported habitual sleep duration and disruption, these traits are heritable⁴¯⁹ and identification of the genes involved should improve understanding of sleep, mechanisms linking sleep to disease and development of new therapies. We report single- and multiple-trait genome-wide association analyses of self-reported sleep duration, insomnia symptoms and excessive daytime sleepiness in the UK Biobank (n = 112,586). We discover loci associated with insomnia symptoms (near MEIS1, TMEM132E, CYCL1 and TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR–OPHN1) and a composite sleep trait (near PATJ (INADL) and HCRTR2) and replicate a locus associated with sleep duration (at PAX8). We also observe genetic correlation between longer sleep duration and schizophrenia risk (rg = 0.29, P = 1.90 × 10−¹³) and between increased levels of excessive daytime sleepiness and increased measures for adiposity traits (body mass index (BMI): rg = 0.20, P = 3.12 × 10⁻⁹; waist circumference: rg = 0.20, P = 2.12 × 10⁻⁷). |
Keywords: | Behavioural genetics; genome-wide association studies |
Rights: | © 2017 Nature America, Inc., part of Springer Nature. All rights reserved. |
DOI: | 10.1038/ng.3749 |
Published version: | http://dx.doi.org/10.1038/ng.3749 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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