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https://hdl.handle.net/2440/104845
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Type: | Journal article |
Title: | Effect of surface chemical functionalities on collagen deposition by primary human dermal fibroblasts |
Author: | Bachhuka, A. Hayball, J. Smith, L. Vasilev, K. |
Citation: | ACS Applied Materials and Interfaces, 2015; 7(42):23767-23775 |
Publisher: | American Chemical Society |
Issue Date: | 2015 |
ISSN: | 1944-8244 1944-8252 |
Statement of Responsibility: | Akash Bachhuka, John Hayball, Louise E. Smith and K. Vasilev |
Abstract: | Surface modification has been identified as an important technique that could improve the response of the body to implanted medical devices. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, how surface chemistry affects collagen I and III deposition by these cells has not been systematically studied. Here, we report how surface chemistry influences the deposition of collagen I and III by primary human dermal fibroblasts. Amine (NH3), carboxyl acid (COOH), and hydrocarbon (CH3) surfaces were generated by plasma deposition. This is a practically relevant tool to deposit a functional coating on any type of substrate material. We show that fibroblasts adhere better and proliferate faster on amine-rich surfaces. In addition, the initial collagen I and III production is greater on this type of coating. These data indicates that surface modification can be a promising route for modulating the rate and level of fibrous encapsulation and may be useful in informing the design of implantable biomedical devices to produce more predictable clinical outcomes. |
Keywords: | plasma polymerization; surface chemistry; collagen I; collagen III; fibroblasts |
Rights: | © 2015 American Chemical Society |
DOI: | 10.1021/acsami.5b08249 |
Grant ID: | http://purl.org/au-research/grants/arc/DP150104212 |
Published version: | http://dx.doi.org/10.1021/acsami.5b08249 |
Appears in Collections: | Aurora harvest 8 Physics publications |
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