Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105008
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMarathe, C.en
dc.contributor.authorRayner, C.en
dc.contributor.authorLange, K.en
dc.contributor.authorBound, M.en
dc.contributor.authorWishart, J.en
dc.contributor.authorJones, K.en
dc.contributor.authorKahn, S.en
dc.contributor.authorHorowitz, M.en
dc.date.issued2017en
dc.identifier.citationPhysiological Reports, 2017; 5(4):e13122-1-e13122-6en
dc.identifier.issn2051-817Xen
dc.identifier.issn2051-817Xen
dc.identifier.urihttp://hdl.handle.net/2440/105008-
dc.description.abstractThe oral disposition index, the product of the early insulin secretory response during an oral glucose tolerance test and insulin sensitivity, is used widely for both the prediction of, and evaluation of the response to interventions, in type 2 diabetes. Gastric emptying, which determines small intestinal exposure of nutrients, modulates postprandial glycemia. The aim of this study was to determine whether the insulin secretory response and the disposition index (DI) related to gastric emptying in subjects with normal glucose tolerance. Thirty-nine subjects consumed a 350 mL drink containing 75 g glucose labeled with 99mTc-sulfur colloid. Gastric emptying (by scintigraphy), blood glucose (G) and plasma insulin (I) were measured between t = 0-120 min. The rate of gastric emptying was derived from the time taken for 50% emptying (T50) and expressed as kcal/min. The early insulin secretory response was estimated by the ratio of the change in insulin (∆I0-30) to that of glucose at 30 min (∆G0-30) represented as ∆I0-30/∆G0-30 Insulin sensitivity was estimated as 1/fasting insulin and the DI was then calculated as ∆I0-30/∆G0-30 × 1/fasting insulin. There was a direct relationship between ∆G0-30 and gastric emptying (r = 0.47, P = 0.003). While there was no association of either ∆I0-30 (r = -0.16, P = 0.34) or fasting insulin (r = 0.21, P = 0.20), there were inverse relationships between the early insulin secretory response (r = -0.45, P = 0.004) and the DI (r = -0.33, P = 0.041), with gastric emptying. We conclude that gastric emptying is associated with both insulin secretion and the disposition index in subjects with normal glucose tolerance, such that when gastric emptying is relatively more rapid, both the early insulin secretory response and the disposition index are less. These findings should be interpreted as "hypothesis generating" and provide the rationale for longitudinal studies to examine the impact of baseline rate of gastric emptying on the prospective risk of type 2 diabetes.en
dc.description.statementofresponsibilityChinmay S. Marathe, Christopher K. Rayner, Kylie Lange, Michelle Bound, Judith Wishart, Karen L. Jones, Steven E. Kahn and Michael Horowitzen
dc.language.isoenen
dc.publisherPhysiological Society and the American Physiological Societyen
dc.rights© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectGastric emptying; insulin secretory response; oral disposition index; oral glucose tolerance testen
dc.titleRelationships of the early insulin secretory response and oral disposition index with gastric emptying in subjects with normal glucose toleranceen
dc.typeJournal articleen
dc.identifier.rmid0030065234en
dc.identifier.doi10.14814/phy2.13122en
dc.identifier.pubid290352-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_105008.pdfPublished version245.8 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.