Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105041
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Type: Journal article
Title: Automated quantification of atrial fibrillation complexity by probabilistic electrogram analysis and fibrillation wave reconstruction
Author: Zeemering, S.
Maesen, B.
Nijs, J.
Lau, D.
Granier, M.
Verheule, S.
Schotten, U.
Citation: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012; 2012:6357-6360
Publisher: IEEE
Issue Date: 2012
ISSN: 1094-687X
1557-170X
Statement of
Responsibility: 
S. Zeemering, B. Maesen, J. Nijs, D. H. Lau, M. Granier, S. Verheule, and U. Schotten
Abstract: The analysis of high-density activation maps of atrial fibrillation (AF) provides fundamental insights into the fibrillation wave propagation patterns and thus the mechanisms of AF. Current annotation of local activations in unipolar atrial electrograms and the construction of fibrillation waves require labor-intensive manual editing. To enhance the possibilities for spatiotemporal analysis of AF, we developed a rapid and fully automated procedure to accurately identify local, intrinsic atrial deflections and construct fibrillation waves based on these deflections. In this study, the automated procedure was validated using manually annotated electrograms and wave maps. We show that the novel procedure accurately detects intrinsic deflections (sensitivity=87%, positive predictive value=89%) and that reconstructed wave maps correlate well with manually edited wave maps in terms of number of waves (r=0.96), intra-wave conduction velocity (r=0.97), AF cycle length (r=0.97), and wave size (r=0.96) (p<0.01 in all cases). The automated procedure is therefore an adequate substitute for manual annotation.
Keywords: Atrial Fibrillation
Description: Published as 34th Annual International Conference of the IEEE EMBS San Diego, California USA, 28 August - 1 September, 2012. ISBN: 9781424441198
Rights: ©2012 IEEE
RMID: 0030069352
DOI: 10.1109/EMBC.2012.6347448
Appears in Collections:Medicine publications

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