Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105210
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Type: Journal article
Title: Evaluation of three algorithms for the segmentation of overlapping cervical cells
Author: Lu, Z.
Carneiro, G.
Bradley, A.
Ushizima, D.
Nosrati, M.
Bianchi, A.
Carneiro, C.
Hamarneh, G.
Citation: IEEE Journal of Biomedical and Health Informatics, 2017; 21(2):441-450
Publisher: Institute of Electrical and Electronics Engineers
Issue Date: 2017
ISSN: 2168-2194
2168-2208
Statement of
Responsibility: 
Zhi Lu, Gustavo Carneiro, Andrew P. Bradley, Daniela Ushizima, Masoud S. Nosrati, Andrea G. C. Bianchi, Claudia M. Carneiro, Ghassan Hamarneh
Abstract: In this paper, we introduce and evaluate the systems submitted to the first Overlapping Cervical Cytology Image Segmentation Challenge, held in conjunction with the IEEE International Symposium on Biomedical Imaging 2014. This challenge was organized to encourage the development and benchmarking of techniques capable of segmenting individual cells from overlapping cellular clumps in cervical cytology images, which is a prerequisite for the development of the next generation of computer-aided diagnosis systems for cervical cancer. In particular, these automated systems must detect and accurately segment both the nucleus and cytoplasm of each cell, even when they are clumped together and, hence, partially occluded. However, this is an unsolved problem due to the poor contrast of cytoplasm boundaries, the large variation in size and shape of cells, and the presence of debris and the large degree of cellular overlap. The challenge initially utilized a database of 16 high-resolution (×40 magnification) images of complex cellular fields of view, in which the isolated real cells were used to construct a database of 945 cervical cytology images synthesized with a varying number of cells and degree of overlap, in order to provide full access of the segmentation ground truth. These synthetic images were used to provide a reliable and comprehensive framework for quantitative evaluation on this segmentation problem. Results from the submitted methods demonstrate that all the methods are effective in the segmentation of clumps containing at most three cells, with overlap coefficients up to 0.3. This highlights the intrinsic difficulty of this challenge and provides motivation for significant future improvement.
Keywords: Image segmentation; training; cells (biology); informatics; testing; cervical cancer; manuals; challenge; overlapping cell segmentation; pap smear image analysis
Rights: © 2016 IEEE.
RMID: 0030067627
DOI: 10.1109/JBHI.2016.2519686
Grant ID: http://purl.org/au-research/grants/arc/FT110100623
http://purl.org/au-research/grants/arc/DP140102794
Appears in Collections:Computer Science publications

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