Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105898
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression |
Author: | Loo, C. Gálvez, V. O'Keefe, E. Mitchell, P. Hadzi-Pavlovic, D. Leyden, J. Harper, S. Somogyi, A. Lai, R. Weickert, C. Glue, P. |
Citation: | Acta Psychiatrica Scandinavica, 2016; 134(1):48-56 |
Publisher: | Wiley |
Issue Date: | 2016 |
ISSN: | 0001-690X 1600-0447 |
Statement of Responsibility: | C.K. Loo, V. Gálvez, E. O’Keefe, P.B. Mitchell, D. Hadzi-Pavlovic, J. Leyden, S. Harper, A.A. Somogyi, R. Lai, C.S. Weickert, P. Glue |
Abstract: | Objective: This pilot study assessed the feasibility, efficacy and safety of an individual dose-titration approach, and of the intravenous (IV), intramuscular (IM) and subcutaneous (SC) routes for treating depression with ketamine. Method: Fifteen treatment-refractory depressed participants received ketamine or midazolam (control treatment) in a multiple crossover, double-blind study. Ketamine was administered by IV (n = 4), IM (n = 5) or SC (n = 6) injection. Dose titration commenced at 0.1 mg/kg, increasing by 0.1 mg/kg up to 0.5 mg/kg, given in separate treatment sessions separated by ≥1 week, with one placebo control treatment randomly inserted. Mood, psychotomimetic and hemodynamic effects were assessed and plasma ketamine concentrations assayed. Results: Twelve participants achieved response and remission criteria, achieved at doses as low as 0.1 mg/kg. All three routes of administration resulted in comparable antidepressant effects. Fewest adverse effects were noted with the SC route. Antidepressant response, adverse effects and ketamine concentrations were dose-related. Conclusion: Antidepressant response occurred at a range of doses and at <0.5 mg/kg. The dose-titration approach is a practical method for optimizing the efficacy - side-effects trade-off on an individual patient basis. This pilot study provides preliminary evidence for SC injection as a practical, feasible and efficacious treatment approach. |
Keywords: | Ketamine; dose titration; intraveneous; intramuscular; intranasal |
Rights: | © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
DOI: | 10.1111/acps.12572 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1021970 |
Published version: | http://dx.doi.org/10.1111/acps.12572 |
Appears in Collections: | Aurora harvest 8 Pharmacology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.