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|Title:||Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure|
|Citation:||Biomedical Optics Express, 2014; 5(7):2113-2124|
|Publisher:||Optical Society of America|
|Brendan F. Kennedy, Robert A. McLaughlin, Kelsey M. Kennedy, Lixin Chin, Andrea Curatolo, Alan Tien, Bruce Latham, Christobel M. Saunders and David D. Sampson|
|Abstract:||We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of the complex OCT signal and weighted least-squares regression. Using three-dimensional phase unwrapping, we have increased the maximum detectable strain eleven-fold over no unwrapping and the minimum detectable strain is 2.6 με. We demonstrate the potential of mechanical over optical contrast for visualizing micro-scale tissue structures in human breast cancer pathology and lymph node morphology.|
|Keywords:||(100.5088) Phase unwrapping; (110.1650) Coherence imaging; (110.4500) Optical coherence tomography|
|Rights:||© 2014 Optical Society of America|
|Appears in Collections:||Physics publications|
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