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https://hdl.handle.net/2440/106197
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dc.contributor.author | Kennedy, B. | - |
dc.contributor.author | Mclaughlin, R. | - |
dc.contributor.author | Kennedy, K. | - |
dc.contributor.author | Chin, L. | - |
dc.contributor.author | Curatolo, A. | - |
dc.contributor.author | Tien, A. | - |
dc.contributor.author | Latham, B. | - |
dc.contributor.author | Saunders, C. | - |
dc.contributor.author | Sampson, D. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Biomedical Optics Express, 2014; 5(7):2113-2124 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | http://hdl.handle.net/2440/106197 | - |
dc.description.abstract | We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of the complex OCT signal and weighted least-squares regression. Using three-dimensional phase unwrapping, we have increased the maximum detectable strain eleven-fold over no unwrapping and the minimum detectable strain is 2.6 με. We demonstrate the potential of mechanical over optical contrast for visualizing micro-scale tissue structures in human breast cancer pathology and lymph node morphology. | - |
dc.description.statementofresponsibility | Brendan F. Kennedy, Robert A. McLaughlin, Kelsey M. Kennedy, Lixin Chin, Andrea Curatolo, Alan Tien, Bruce Latham, Christobel M. Saunders and David D. Sampson | - |
dc.language.iso | en | - |
dc.publisher | Optical Society of America | - |
dc.rights | © 2014 Optical Society of America | - |
dc.source.uri | http://dx.doi.org/10.1364/boe.5.002113 | - |
dc.subject | (100.5088) Phase unwrapping | - |
dc.subject | (110.1650) Coherence imaging | - |
dc.subject | (110.4500) Optical coherence tomography | - |
dc.title | Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1364/BOE.5.002113 | - |
dc.relation.grant | ARC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mclaughlin, R. [0000-0001-6947-5061] | - |
Appears in Collections: | Aurora harvest 8 Physics publications |
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