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Type: Journal article
Title: Therapeutic potential of nitroxyl (HNO) donors in the management of acute decompensated heart failure
Author: Kemp-Harper, B.
Horowitz, J.
Ritchie, R.
Citation: Drugs, 2016; 76(14):1337-1348
Publisher: Springer International Publishing
Issue Date: 2016
ISSN: 0012-6667
Statement of
Barbara K. Kemp-Harper, John D. Horowitz, Rebecca H. Ritchie
Abstract: Heart failure (HF) is a major cause of hospital admission in the Western world, yet there remains a paucity of effective pharmacological management options. With the recent development of synthetic, next-generation nitroxyl (HNO) donors and their progress into clinical trials, it is timely to now provide an update on the therapeutic potential of HNO donors in the management of acute decompensated heart failure. In this article, we summarize current understanding of the pharmacology of HNO (in comparison with its redox sibling, nitric oxide), its spectrum of cardioprotective actions, and efforts to translate these into the clinic. Future research directions for this exciting new class of HF drugs are also considered.
Keywords: Heart Failure
Description: Published online: 26 August 2016
Rights: © Springer International Publishing Switzerland 2016
RMID: 0030073011
DOI: 10.1007/s40265-016-0631-y
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Appears in Collections:Medicine publications

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