Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106591
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Type: Journal article
Title: The timing of discharge from the Intensive Care Unit and subsequent mortality: a prospective, multicenter study
Author: Santamaria, J.
Duke, G.
Pilcher, D.
Cooper, D.
Moran, J.
Bellomo, R.
Citation: American Journal of Respiratory and Critical Care Medicine, 2015; 191(9):1033-1039
Publisher: American Thoracic Society
Issue Date: 2015
ISSN: 1073-449X
1535-4970
Statement of
Responsibility: 
John D. Santamaria, Graeme J. Duke, David V. Pilcher, D. James Cooper, John Moran, and Rinaldo Bellomo (The Discharge and Readmission Evaluation (DARE) Study)
Abstract: Rationale: Previous studies suggested an association between after-hours intensive care unit (ICU) discharge and increased hospital mortality. Their retrospective design and lack of correction for patient factors present at the time of discharge make this association problematic. Objectives: To determine factors independently associated with mortality after ICU discharge. Methods: This was a prospective, multicenter, binational observational study involving 40 ICUs in Australia and New Zealand. Participants were consecutive adult patients discharged alive from the ICU between September 2009 and February 2010. Measurements and Main Results: We studied 10,211 patients discharged alive from the ICU. Median age was 63 years (interquartile range, 49-74), 6,224 (61%) were male, 5,707 (56%) required mechanical ventilation, and their median Acute Physiology and Chronic Health Evaluation III risk of death was 9% (interquartile range, 3-25%). A total of 8,539 (83.6%) patients were discharged in-hours (06:00-18:00) and 1,672 (16.4%) after-hours (18:00-06:00). Of these, 408 (4.8%) and 124 (7.4%), respectively, subsequently died in hospital (P < 0.001). After risk adjustment for markers of illness severity at time of ICU discharge including limitations of medical therapy (LOMT) orders, the time of discharge was no longer a significant predictor of mortality. The presence of a LOMT order was the strongest predictor of death (odds ratio, 35.4; 95% confidence interval, 27.5-45.6). CONCLUSIONS: In this large, prospective, multicenter, binational observational study, we found that patient status at ICU discharge, particularly the presence of LOMT orders, was the chief predictor of hospital survival. In contrast to previous studies, the timing of discharge did not have an independent association with mortality.
Keywords: Hospital mortality; intensive care unit; after-hours care; patient transfer; risk factors
Rights: Copyright © 2015 by the American Thoracic Society
RMID: 0030036485
DOI: 10.1164/rccm.201412-2208OC
Appears in Collections:Anaesthesia and Intensive Care publications

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