Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107074
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Type: Journal article
Title: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Author: Graff, M.
Scott, R.
Justice, A.
Young, K.
Feitosa, M.
Barata, L.
Winkler, T.
Chu, A.
Mahajan, A.
Hadley, D.
Xue, L.
Workalemahu, T.
Heard-Costa, N.
den Hoed, M.
Ahluwalia, T.
Qi, Q.
Ngwa, J.
Renström, F.
Quaye, L.
Eicher, J.
et al.
Citation: PLoS Genetics, 2017; 13(4):e1006528-1-e1006528-26
Publisher: Public Library of Science
Issue Date: 2017
ISSN: 1553-7390
1553-7404
Statement of
Responsibility: 
Mariaelisa Graff ... Lyle J. Palmer ... et al.
Abstract: Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Keywords: Body mass index; genome-wide association study
Rights: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
RMID: 0030068989
DOI: 10.1371/journal.pgen.1006528
Grant ID: http://purl.org/au-research/grants/nhmrc/241944
http://purl.org/au-research/grants/nhmrc/339462
http://purl.org/au-research/grants/nhmrc/389927
http://purl.org/au-research/grants/nhmrc/389875
http://purl.org/au-research/grants/nhmrc/389891
http://purl.org/au-research/grants/nhmrc/389892
http://purl.org/au-research/grants/nhmrc/389938
http://purl.org/au-research/grants/nhmrc/442915
http://purl.org/au-research/grants/nhmrc/442981
http://purl.org/au-research/grants/nhmrc/496739
http://purl.org/au-research/grants/nhmrc/552485
http://purl.org/au-research/grants/nhmrc/552498
Appears in Collections:Translational Health Science publications

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