Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107111
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Type: Journal article
Title: Association of maternal diabetes/glycosuria and pre-pregnancy body mass index with offspring indicators of non-alcoholic fatty liver disease
Author: Patel, S.
Lawlor, D.
Callaway, M.
Macdonald-Wallis, C.
Sattar, N.
Fraser, A.
Citation: BMC Pediatrics, 2016; 16(1):47-1-47-13
Publisher: BioMed Central
Issue Date: 2016
ISSN: 1471-2431
1471-2431
Statement of
Responsibility: 
Sumaiya Patel, Debbie A. Lawlor, Mark Callaway, Corrie Macdonald-Wallis, Naveed Sattar and Abigail Fraser
Abstract: Background: Little is known about early life determinants of non-alcoholic fatty liver disease (NAFLD). We examined associations of maternal pregnancy diabetes/glycosuria and pre-pregnancy body mass index (BMI) with offspring markers of NAFLD and liver pathology and examined mediation by birthweight and concurrent offspring adiposity. Methods: We used data from a UK prospective pregnancy cohort. Offspring underwent abdominal ultrasonography (USS) at mean age 17.8 years. Outcomes included USS-assessed fatty liver, estimated liver volume and shear velocity, a variant of elastography (a marker of liver fibrosis) (N = 1 215) and blood-based markers of liver pathology [alanine amino transferase, aspartate amino transferase, gamma- glutamyltransferase and haptoglobin] (N = 2 359). Results: 2.1 % (N = 25) of participants had USS-assessed fatty liver [maternal diabetes/glycosuria (N = 7) and no diabetes/glycosuria (N = 18)]. Maternal diabetes/glycosuria was associated with greater odds of offspring USS fatty liver in confounder adjusted models [adjusted odds ratio (aOR) 6.74 (95 % confidence interval (CI) 2.47, 18.40)] and higher shear velocity [adjusted ratio of geometric mean (aRGM):1.10 (95 % CI 1.05, 1.15)]. These associations were not mediated by offspring birthweight or concurrent adiposity. Maternal diabetes/glycosuria was not associated with liver volume or blood-based outcomes. Greater maternal pre-pregnancy BMI was associated with greater odds of offspring USS fatty liver [aOR 2.72 (95 % CI: 1.20, 6.15)], higher liver volume [aRGM 1.03 (95 % CI 1.00, 1.07)] and shear velocity [aRGM1.03 (95 % CI: 1.01, 1.06)] in confounder adjusted models. These associations were largely mediated by offspring adiposity. Maternal pre-pregnancy BMI was not consistently associated with blood-based outcomes. Conclusions: Results suggest that maternal pregnancy diabetes/glycosuria is associated with offspring NAFLD through mechanisms other than offspring’s own adiposity.
Keywords: Pregnancy diabetes; glycosuria; obesity; NAFLD; fetal overnutrition; ALSPAC
Rights: © Patel et al. 2016
RMID: 0030047722
DOI: 10.1186/s12887-016-0585-y
Appears in Collections:Paediatrics publications

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