Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107157
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Type: Journal article
Title: Gestational-age-specific reference ranges for blood pressure in pregnancy: findings from a prospective cohort
Author: Macdonald-Wallis, C.
Silverwood, R.
Fraser, A.
Nelson, S.
Tilling, K.
Lawlor, D.
De Stavola, B.
Citation: Journal of Hypertension, 2015; 33(1):96-105
Publisher: Lippincott Williams & Wilkins
Issue Date: 2015
ISSN: 0263-6352
1473-5598
Statement of
Responsibility: 
Corrie Macdonald-Wallis, Richard J. Silverwood, Abigail Fraser, Scott M. Nelson, Kate Tilling, Debbie A. Lawlor and Bianca L. de Stavola
Abstract: Objective: Pregnancy is a period of considerable change in blood pressure, with an early pregnancy decrease followed by a late pregnancy rise. High blood pressure in pregnancy is associated with adverse perinatal outcomes for the mother and offspring. We aimed to define normal ranges of blood pressure across gestation. Methods: We used repeated antenatal blood pressure measurements [median (interquartile range) 10 (9–11) per woman] for 10 327 women. Multilevel models were used to derive longitudinal reference ranges for SBP and DBP from 12 to 40 weeks gestation for the whole cohort, for women with normal pregnancies (without essential hypertension or preeclampsia who delivered an appropriate-size-for-gestational age infant at term) and for subgroups of normal pregnancies defined by different levels of maternal prepregnancy BMI, smoking and parity. Results: In normal pregnancies, the mean (95% reference range) SBP and DBP for nulliparous women at 12 weeks gestation were 112.1 (88.6–135.5) and 65.4 (48.9–81.9) mmHg, and at 37 weeks were 116.0 (92.3–139.7) and 70.0 (52.2–87.9) mmHg, respectively. For every additional 10 mmHg of blood pressure at 12 weeks, normal ranges were 2–3 mmHg higher across gestation. Reference ranges for multiparous women were 1–2 mmHg lower throughout pregnancy. Stratified reference ranges were higher for women in higher prepregnancy BMI categories, and lower for smokers than for nonsmokers throughout pregnancy. Conclusion: Normal ranges for blood pressure vary with gestation age and by maternal subgroups. Whole population and stratified normograms could be used as a reference to identify abnormal trajectories.
Keywords: Avon Longitudinal Study of Parents and Children; blood pressure; longitudinal; pregnancy; reference range
Rights: ©2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030041753
DOI: 10.1097/HJH.0000000000000368
Appears in Collections:Medicine publications

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