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Type: Journal article
Title: Solar insolation in springtime influences age of onset of bipolar I disorder
Author: Bauer, M.
Glenn, T.
Alda, M.
Aleksandrovich, M.
Andreassen, O.
Angelopoulos, E.
Ardau, R.
Ayhan, Y.
Baethge, C.
Bharathram, S.
Bauer, R.
Baune, B.
Becerra-Palars, C.
Bellivier, F.
Belmaker, R.
Berk, M.
Bersudsky, Y.
Bicakci, S.
Birabwa-Oketcho, H.
Bjella, T.
et al.
Citation: Acta Psychiatrica Scandinavica, 2017; 136(6):571-582
Publisher: John Wiley & Sons
Issue Date: 2017
ISSN: 0001-690X
Statement of
M. Bauer ... B. Baune ... et al.
Abstract: Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.
Keywords: bipolar disorder; circadian rhythm; epidemiology; solar insolation
Description: Accepted for publication June 16, 2017
Rights: © 2017 John Wiley & Sons A/S
RMID: 0030073173
DOI: 10.1111/acps.12772
Grant ID:
Appears in Collections:Medical Sciences publications

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