Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/109309
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dc.contributor.authorWade, K.en
dc.contributor.authorForouhi, N.en
dc.contributor.authorCook, D.en
dc.contributor.authorJohnson, P.en
dc.contributor.authorMcConnachie, A.en
dc.contributor.authorMorris, R.en
dc.contributor.authorRodriguez, S.en
dc.contributor.authorYe, Z.en
dc.contributor.authorEbrahim, S.en
dc.contributor.authorPadmanabhan, S.en
dc.contributor.authorWatt, G.en
dc.contributor.authorBruckdorfer, K.en
dc.contributor.authorWareham, N.en
dc.contributor.authorWhincup, P.en
dc.contributor.authorChanock, S.en
dc.contributor.authorSattar, N.en
dc.contributor.authorLawlor, D.en
dc.contributor.authorSmith, G.en
dc.contributor.authorTimpson, N.en
dc.date.issued2015en
dc.identifier.citationAmerican Journal of Clinical Nutrition, 2015; 101(1):202-209en
dc.identifier.issn0002-9165en
dc.identifier.issn1938-3207en
dc.identifier.urihttp://hdl.handle.net/2440/109309-
dc.description.abstractBackground: Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and reverse causation. Objectives: We assessed the relation between L-ascorbic acid and 10 cardiometabolic traits by using a single nucleotide polymorphism in the solute carrier family 23 member 1 (SLC23A1) gene (rs33972313) associated with circulating L-ascorbic acid concentrations. The observed association between rs33972313 and cardiometabolic outcomes was compared with that expected given the rs33972313-L-ascorbic acid and L-ascorbic acid-outcome associations. Design: A meta-analysis was performed in the following 5 independent studies: the British Women's Heart and Health Study (n = 1833), the MIDSPAN study (n = 1138), the Ten Towns study (n = 1324), the British Regional Heart Study (n = 2521), and the European Prospective Investigation into Cancer (n = 3737). Results: With the use of a meta-analysis of observational estimates, inverse associations were shown between L-ascorbic acid and systolic blood pressure, triglycerides, and the waist-hip ratio [the strongest of which was the waist-hip ratio (-0.13-SD change; 95% CI: -0.20-, -0.07-SD change; P = 0.0001) per SD increase in L-ascorbic acid], and a positive association was shown with high-density lipoprotein (HDL) cholesterol. The variation at rs33972313 was associated with a 0.18-SD (95% CI: 0.10-, 0.25-SD; P = 3.34 × 10⁻⁶) increase in L-ascorbic acid per effect allele. There was no evidence of a relation between the variation at rs33972313 and any cardiometabolic outcome. Although observed estimates were not statistically different from expected associations between rs33972313 and cardiometabolic outcomes, estimates for low-density lipoprotein cholesterol, HDL cholesterol, triglycerides, glucose, and body mass index were in the opposite direction to those expected.The nature of the genetic association exploited in this study led to limited statistical application, but despite this, when all cardiometabolic traits were assessed, there was no evidence of any trend supporting a protective role of L-ascorbic acid. In the context of existing work, these results add to the suggestion that observational relations between L-ascorbic acid and cardiometabolic health may be attributable to confounding and reverse causation.en
dc.description.statementofresponsibilityKaitlin H Wade, Nita G Forouhi, Derek G Cook, Paul Johnson, Alex McConnachie, Richard W Morris, Santiago Rodriguez, Zheng Ye, Shah Ebrahim, Sandosh Padmanabhan, Graham Watt, K Richard Bruckdorfer, Nick J Wareham, Peter H Whincup, Stephen Chanock, Naveed Sattar, Debbie A Lawlor, George Davey Smith and Nicholas J Timpsonen
dc.language.isoenen
dc.publisherAmerican Society for Nutritionen
dc.rightsThis is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).en
dc.subjectl-ascorbic acid; cardiometabolic traits; confounding; genetic variants; reverse causationen
dc.titleVariation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic aciden
dc.typeJournal articleen
dc.identifier.rmid0030042373en
dc.identifier.doi10.3945/ajcn.114.092981en
dc.identifier.pubid232726-
pubs.library.collectionMedical Sciences publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medical Sciences publications

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