Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111727
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Type: Journal article
Title: Plant cation-chloride cotransporters (CCC): evolutionary origins and functional insights
Author: Henderson, S.
Wege, S.
Gilliham, M.
Citation: International Journal of Molecular Sciences, 2018; 19(2):492-1-492-12
Publisher: MDPI
Issue Date: 2018
ISSN: 1661-6596
1422-0067
Statement of
Responsibility: 
Sam W. Henderson, Stefanie Wege and Matthew Gilliham
Abstract: Genomes of unicellular and multicellular green algae, mosses, grasses and dicots harbor genes encoding cation-chloride cotransporters (CCC). CCC proteins from the plant kingdom have been comparatively less well investigated than their animal counterparts, but proteins from both plants and animals have been shown to mediate ion fluxes, and are involved in regulation of osmotic processes. In this review, we show that CCC proteins from plants form two distinct phylogenetic clades (CCC1 and CCC2). Some lycophytes and bryophytes possess members from each clade, most land plants only have members of the CCC1 clade, and green algae possess only the CCC2 clade. It is currently unknown whether CCC1 and CCC2 proteins have similar or distinct functions, however they are both more closely related to animal KCC proteins compared to NKCCs. Existing heterologous expression systems that have been used to functionally characterize plant CCC proteins, namely yeast and Xenopus laevis oocytes, have limitations that are discussed. Studies from plants exposed to chemical inhibitors of animal CCC protein function are reviewed for their potential to discern CCC function in planta. Thus far, mutations in plant CCC genes have been evaluated only in two species of angiosperms, and such mutations cause a diverse array of phenotypes-seemingly more than could simply be explained by localized disruption of ion transport alone. We evaluate the putative roles of plant CCC proteins and suggest areas for future investigation.
Keywords: KCC; NKCC; plant membrane transport; plant nutrition; anion; Golgi; plasma membrane; AT1G30450; Arabidopsis
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
RMID: 0030081531
DOI: 10.3390/ijms19020492
Grant ID: http://purl.org/au-research/grants/arc/DE160100804
http://purl.org/au-research/grants/arc/FT130100709
http://purl.org/au-research/grants/arc/CE140100008
Appears in Collections:Agriculture, Food and Wine publications

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