Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111805
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dc.contributor.authorDuncan, J.en
dc.contributor.authorGarland, M.en
dc.contributor.authorStark, R.en
dc.contributor.authorMyers, M.en
dc.contributor.authorFifer, W.en
dc.contributor.authorMokler, D.en
dc.contributor.authorKinney, H.en
dc.date.issued2015en
dc.identifier.citationBrain Pathology, 2015; 25(2):171-181en
dc.identifier.issn1015-6305en
dc.identifier.issn1750-3639en
dc.identifier.urihttp://hdl.handle.net/2440/111805-
dc.description.abstractExposure to nicotine during pregnancy via maternal cigarette smoking is associated with visual deficits in children. This is possibly due to the activation of nicotinic acetylcholine receptors (nAChRs) in the occipital cortex, which are important in the development of visual mapping. Using a baboon model, we explored the effects of prenatal nicotine on parameters in the primary and associated visual cortices. Pregnant baboons were infused with nicotine (0.5 mg/h, intravenous) or saline from 86 days gestation. At 161 days gestation, fetal brains were collected (n = 5 per group) and the occipital lobe assessed for nAChRs and markers of the serotonergic and catecholaminergic systems using tissue autoradiography and/or high-performance liquid chromatography. Neuronal nAChRs and serotonergic markers were expressed in a region- and subunit-dependent manner. Prenatal nicotine exposure was associated with increased binding for (3) H-epibatidine sensitive nAChRs in the primary visual cortex [Brodmann areas (BA) 17] and BA 18, but not BA 19, of the associative visual cortex (P < 0.05). Markers of the serotonergic or catecholaminergic systems were not significantly altered. Thus, prenatal nicotine exposure is associated with alterations in the cholinergic system in the occipital lobe, which may aid in the explanation of the appearance of visual deficits in children from mothers who smoke during pregnancy.en
dc.description.statementofresponsibilityJhodie R. Duncan, Marianne Garland, Raymond I. Stark, Michael M. Myers, William P. Fifer, David J. Mokler, Hannah C. Kinneyen
dc.language.isoenen
dc.publisherInternational Society of Neuropathologyen
dc.rights© 2014 International Society of Neuropathologyen
dc.subjectCalcarine sulcus; nicotinic receptors; pregnancy; serotonin; smoking; visual cortexen
dc.titlePrenatal nicotine exposure selectively affects nicotinic receptor expression in primary and associative visual cortices of the fetal baboonen
dc.typeJournal articleen
dc.identifier.rmid0030084258en
dc.identifier.doi10.1111/bpa.12165en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/359250en
dc.relation.granthttp://purl.org/au-research/grants/arc/FT100100235en
dc.identifier.pubid401450-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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