Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11267
Type: Journal article
Title: An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13
Author: Schulz, T. C.
Hopwood, Blair
Rathjen, Peter David
Wells, J. R. E.
Citation: Biochemical Journal, 1995; 311(1):219-224
Publisher: Biochemical Society
Issue Date: 1995
ISSN: 0264-6021
Abstract: The zinc finger is a protein domain that imparts specific nucleic acid-binding activity on a wide range of functionally important proteins. In this paper we report the molecular cloning and characterization of a novel murine zinc-finger gene, mZ13. Analysis of mZ13 cDNAs revealed that the gene expresses a 794-amino-acid protein encoded by a 2.7 kb transcript. The protein has an unusual arrangement of 13 zinc fingers into a 'hand' of 12 tandem fingers and a single isolated finger near the C-terminus. This structural organization is conserved with the probable chicken homologue, cZ13. mZ13 also contained an additional domain at the N-terminus which has previously been implicated in the regulation of zinc-finger transcription factor DNA-binding, via protein-protein interactions. mZ13 expression was detected in a wide range of murine embryonic and adult tissues. The structural organization of mZ13 and its expression profile suggest that it may function as a housekeeping DNA-binding protein that regulates the expression of specific genes.
Description (link): http://www.ncbi.nlm.nih.gov/pubmed/7575457
Appears in Collections:Biochemistry publications

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