Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112707
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Type: Journal article
Title: Metastasis of ovarian cancer is mediated by kallikrein related peptidases
Author: Dong, Y.
Loessner, D.
Irving-Rodgers, H.
Obermair, A.
Nicklin, J.
Clements, J.
Citation: Clinical & Experimental Metastasis, 2014; 31(1):135-147
Publisher: Springer Netherlands
Issue Date: 2014
ISSN: 0262-0898
1573-7276
Statement of
Responsibility: 
Ying Dong, Daniela Loessner, Helen Irving-Rodgers, Andreas Obermair, James L. Nicklin, Judith A. Clements
Abstract: Ovarian cancer, in particular epithelial ovarian cancer (EOC), is commonly diagnosed when the tumor has metastasized into the abdominal cavity with an accumulation of ascites fluid. Combining histopathology and genetic variations, EOC can be sub-grouped into Type-I and Type-II tumors, of which the latter are more aggressive and metastatic. Metastasis and chemoresistance are the key events associated with the tumor microenvironment that lead to a poor patient outcome. Kallikrein-related peptidases (KLKs) are aberrantly expressed in EOC, in particular, in the more metastatic Type-II tumors. KLKs are a family of 15 serine proteases that are expressed in diverse human tissues and involved in various patho-physiological processes. As extracellular enzymes, KLKs function in the hydrolysis of growth factors, proteases, cell membrane bound receptors, adhesion proteins, and cytokines initiating intracellular signaling pathways and their downstream events. High KLK levels are differentially associated with the prognosis of ovarian cancer patients, suggesting that they not only have application as biomarkers but also function in disease progression, and therefore are potential therapeutic targets. Recent studies have demonstrated the function of these proteases in promoting and/or suppressing the invasive behavior of ovarian cancer cells in metastasis in vitro and in vivo. Both conventional cell culture methods and three-dimensional platforms have been applied to mimic the ovarian cancer microenvironment of patients, such as the solid stromal matrix and ascites fluid. Here we summarize published studies to provide an overview of our understanding of the role of KLKs in EOC, and to lay the foundation for future research directions.
Keywords: Kallikrein-related peptidases; serous ovarian cancer; ascites microenvironment; multicellular aggregation; chemoresistance; metastasis
Description: Published online: 17 September 2013
Rights: © The Author(s) 2013. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
RMID: 0030090076
DOI: 10.1007/s10585-013-9615-4
Grant ID: http://purl.org/au-research/grants/nhmrc/550523
Appears in Collections:Obstetrics and Gynaecology publications

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