Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/112780
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dc.contributor.authorSadeghi, M.en
dc.contributor.authorErickson, A.en
dc.contributor.authorCastro, J.en
dc.contributor.authorDeiteren, A.en
dc.contributor.authorHarrington, A.en
dc.contributor.authorGrundy, L.en
dc.contributor.authorAdams, D.en
dc.contributor.authorBrierley, S.en
dc.date.issued2018en
dc.identifier.citationInternational Journal of Biochemistry and Cell Biology, 2018; 98:10-23en
dc.identifier.issn1357-2725en
dc.identifier.issn1878-5875en
dc.identifier.urihttp://hdl.handle.net/2440/112780-
dc.description.abstractIrritable bowel syndrome and inflammatory bowel disease are major forms of chronic visceral pain, which affect over 15% of the global population. In order to identify new therapies, it is important to understand the underlying causes of chronic visceral pain. This review provides recent evidence demonstrating that inflammation or infection of the gastrointestinal tract triggers specific changes in the neuronal excitability of sensory pathways responsible for the transmission of nociceptive information from the periphery to the central nervous system. Specific changes in the expression and function of a variety of ion channels and receptors have been documented in inflammatory and chronic visceral pain conditions relevant to irritable bowel syndrome and inflammatory bowel disease. An increase in pro-nociceptive mechanisms enhances peripheral drive from the viscera and provides an underlying basis for enhanced nociceptive signalling during chronic visceral pain states. Recent evidence also highlights increases in anti-nociceptive mechanisms in models of chronic visceral pain, which present novel targets for pharmacological treatment of this condition.en
dc.description.statementofresponsibilityMahsa Sadeghi, Andelain Erickson, Joel Castro, Annemie Deiteren, Andrea M. Harrington, Luke Grundy, David J. Adams, Stuart M. Brierleyen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2018 Elsevier Ltd. All rights reserved.en
dc.subjectAfferents; Colon; Ion channels; Nociception; Painen
dc.titleContribution of membrane receptor signalling to chronic visceral painen
dc.typeJournal articleen
dc.identifier.rmid0030083105en
dc.identifier.doi10.1016/j.biocel.2018.02.017en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1126378en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1083480en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1139366en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1140297en
dc.relation.granthttp://purl.org/au-research/grants/arc/DE130100223en
dc.relation.granthttp://purl.org/au-research/grants/arc/DP180101395en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1072113en
dc.identifier.pubid398197-
pubs.library.collectionBiochemistry publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCastro, J. [0000-0002-5781-2224]en
dc.identifier.orcidHarrington, A. [0000-0002-1562-4137]en
dc.identifier.orcidGrundy, L. [0000-0002-3900-7141]en
dc.identifier.orcidBrierley, S. [0000-0002-2527-2905]en
Appears in Collections:Biochemistry publications

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