Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||CRLF2-positive B-cell acute lymphoblastic leukemia in adult patients : a single-institution experience|
|Citation:||American Journal of Clinical Pathology, 2017; 147(4):357-363|
|Publisher:||American Society for Clinical Pathology|
|Sergej Konoplev, Xinyan Lu, Marina Konopleva, Nitin Jain, Juan Ouyang … Charles G. Mullighan … et al.|
|Abstract:||Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. We analyzed CRLF2 expression and studied its correlation with CRLF2 rearrangement in adult patients with B-ALL.Multiparameter flow cytometry (MFC) was performed consecutively in 126 patients.CRLF2 overexpression was detected in 30 (27%) patients, 28 (41%) of 69 patients with B-ALL not otherwise specified, 14 (21%) of 67 untreated patients, and 16 (27%) of 59 patients with relapsed B-ALL, with the highest among Hispanic patients (25/55, 45%). Of CRLF2+ cases, 21 (100%) of 21 cases showed CRLF2 rearrangement by fluorescence in situ hybridization, preferentially involving IGH@CRLF2 (15/15). The entire coding region of JAK2 was sequenced in 14 patients with CRLF2+ B-ALL, and nine (64%) were positive for JAK2 mutations.MFC allows a rapid, inexpensive, and reliable detection of B-ALL with CRLF2 rearrangement that would further facilitate testing for JAK2 mutations for targetable therapy.|
|Keywords:||B-lymphoblastic leukemia/lymphoma; BCR-ABL1–like; Ph-like B-ALL; CRLF2; Flow cytometry; FISH; JAK2 mutation|
|Rights:||© American Society for Clinical Pathology, 2017. All rights reserved.|
|Appears in Collections:||Genetics publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.