Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11366
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dc.contributor.authorRathjen, Peter Daviden
dc.contributor.authorLake, J.en
dc.contributor.authorWhyatt, L. M.en
dc.contributor.authorBettess, Michael Daviden
dc.contributor.authorRathjen, J.en
dc.date.issued1998en
dc.identifier.citationReproduction Fertility and Development, 1998; 10 (1):31-48en
dc.identifier.issn1031-3613en
dc.identifier.urihttp://hdl.handle.net/2440/11366-
dc.descriptionCopyright © CSIRO 1998en
dc.description.abstractEmbryonic stem cells are pluripotent cells derived from the early mouse embryo that can be propagated stably in the undifferentiated state in vitro. They retain the ability to differentiate into all cell types found in an embryonic and adult mouse in vivo, and can be induced to differentiate into many cell types in vitro. Exploitation of ES cell technology for the creation of mice bearing predetermined genetic alterations has received widespread attention because of the sophistication that it brings to the study of gene function in mammals. Analysis of cell differentiation in vitro has also been of value, leading to the identification of novel bioactive factors and the elucidation of cell specification mechanisms. In this paper, we summarise the features of pluripotent cell lines and their applications, foreshadowing the impact that these systems may have on human biology. While the isolation of definitive human pluripotent cell lines has not yet been achieved, potential applications for these cells in the study of human biology, particularly cell specification, can be envisaged. Of particular interest is the possibility that human embryonic stem cells with properties similar to mouse embryonic stem cells might provide a generic system for gene therapy.en
dc.description.statementofresponsibilityP. D. Rathjen, J. Lake, L. M. Whyatt, M. D. Bettess and J. Rathjenen
dc.language.isoenen
dc.titleProperties and uses of embryonic stem cells: prospects for application to human biology and gene therapyen
dc.typeJournal articleen
dc.contributor.schoolSchool of Molecular and Biomedical Science : Biochemistryen
dc.identifier.doi10.1071/R98041en
Appears in Collections:Biochemistry publications

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