Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113692
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Type: Journal article
Title: Comparative effects of small intestinal glucose on blood pressure, heart rate, and noradrenaline responses in obese and healthy subjects
Author: Trahair, L.
Wu, T.
Feinle-Bisset, C.
Marathe, C.
Rayner, C.
Horowitz, M.
Jones, K.
Citation: Physiological Reports, 2018; 6(4):e13610-1-e13610-8
Publisher: Wiley
Issue Date: 2018
ISSN: 2051-817X
2051-817X
Statement of
Responsibility: 
Laurence G. Trahair, Tongzhi Wu, Christine Feinle-Bisset, Chinmay S. Marathe, Christopher K. Rayner, Michael Horowi and Karen L. Jones
Abstract: Meal consumption leads to an increase in sympathetic output to compensate for hemodynamic changes and maintain blood pressure (BP). Obesity is associated with a blunting of the sympathetic response to meal ingestion, but interpretation of studies investigating these responses is compromised by their failure to account for the rate of gastric emptying, which is an important determinant of postprandial cardiovascular and sympathetic responses and, in both health and obesity, exhibits a wide interindividual variation. We sought to determine the effects of intraduodenal glucose infusion, bypassing gastric emptying, on BP, heart rate (HR), and noradrenaline responses in obese and healthy control subjects. 12 obese subjects (age 36.6 ± 3.9 years, body mass index (BMI) 36.1 ± 1.3 kg/m² ) and 23 controls (age 27.8 ± 2.4 years, BMI 22.4 ± 0.5 kg/m² ) received intraduodenal infusions of glucose at 1 or 3 kcal/min, or saline, for 60 min (t = 0-60 min), followed by intraduodenal saline (t = 60-120 min). BP and HR were measured with an automatic cuff, and blood samples collected for measurement of plasma noradrenaline. Intraduodenal glucose at 1 kcal/min was associated with a fall in diastolic BP in the control subjects only (P < 0.01), with no change in systolic BP, HR or noradrenaline in either group. In both groups, intraduodenal glucose at 3 kcal/min was associated with a fall in diastolic (P < 0.01), but not systolic, BP, and rises in HR (P < 0.001) and plasma noradrenaline (P < 0.01), with no difference in responses between the groups. We conclude that cardiovascular and sympathetic responses to intraduodenal glucose infusion are comparable between obese and control subjects, and dependent on the rate of glucose delivery.
Keywords: Gastric emptying; intraduodenal; sympathetic
Rights: © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
RMID: 0030082376
DOI: 10.14814/phy2.13610
Grant ID: http://purl.org/au-research/grants/nhmrc/627189
http://purl.org/au-research/grants/nhmrc/1103020
Published version: https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.13610
Appears in Collections:Medicine publications

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