Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113698
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Type: Journal article
Title: Histone modifications and their role in epigenetics of atopy and allergic diseases
Author: Alaskhar Alhamwe, B.
Khalaila, R.
Wolf, J.
Bülow, V.
Harb, H.
Alhamdan, F.
Hii, C.
Prescott, S.
Ferrante, A.
Renz, H.
Garn, H.
Potaczek, D.
Citation: Allergy, Asthma and Clinical Immunology, 2018; 14(1):39-1-39-16
Publisher: BioMed Central
Issue Date: 2018
ISSN: 1710-1484
1710-1492
Statement of
Responsibility: 
Bilal Alaskhar Alhamwe, Razi Khalaila, Johanna Wolf, Verena von Bülow, Hani Harb, Fahd Alhamdan, Charles S. Hii, Susan L. Prescott, Antonio Ferrante, Harald Renz, Holger Garn and Daniel P. Potaczek
Abstract: This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development. Together with DNA methylation, histone modifications (including histone acetylation, methylation, phosphorylation, ubiquitination, etc.) represent the classical epigenetic mechanisms. However, much less attention has been given to histone modifications than to DNA methylation in the context of allergy. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of histone modifications in allergy and the mechanisms underlying this development. In addition to covering the growing interest in the contribution of histone modifications in regulating the development of allergic diseases, this review summarizes some of the evidence supporting this contribution. There are at least two levels at which the role of histone modifications is manifested. One is the regulation of cells that contribute to the allergic inflammation (T cells and macrophages) and those that participate in airway remodeling [(myo-) fibroblasts]. The other is the direct association between histone modifications and allergic phenotypes. Inhibitors of histone-modifying enzymes may potentially be used as anti-allergic drugs. Furthermore, epigenetic patterns may provide novel tools in the diagnosis of allergic disorders.
Keywords: Allergy; Asthma; Atopy; Epigenetic (-s); Histone acetylation; Histone methylation; Histone modification (-s); Histone phosphorylation; Inflammation; Immunity
Description: Published online: 23 May 2018
Rights: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creat iveco mmons .org/ publi cdoma in/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
RMID: 0030093851
DOI: 10.1186/s13223-018-0259-4
Grant ID: http://purl.org/au-research/grants/nhmrc/353555
http://purl.org/au-research/grants/nhmrc/513709
Appears in Collections:Paediatrics publications

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