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|Title:||Discovery of a novel long terminal repeat (LTR2i-SS) in Sus Scrofa|
|Citation:||Animal Genetics, 2014; 45(3):367-372|
|Sim L. Lim, R. Daniel Kortschak and David L. Adelson|
|Abstract:||Long terminal repeat (LTR) retrotransposons are transposable elements flanked by 5'/3' LTRs. They have a structure similar to endogenous retroviruses, but they lack the envelope (env) gene making them non-infectious. Long terminal repeats are motif-rich sequences and can act as bidirectional promoters or enhancers to regulate or inactivate genes by insertion. In this study, we identified a new chimeric LTR subfamily, LTR2i_SS, in the pig genome. This chimeric LTR family appears to be the ancestral form of the previously described LTR2_SS family. LTR2_SS appears to have deleted ~300 bp of un-annotated, ancestral sequence from LTR2i_SS. We identified no functional provirus sequences for either of these LTR types. LTR2i_SS sequences have been exapted into the untranslated regions of two protein-coding gene mRNAs. Both of these genes lie within previously mapped pig quantitative trait loci.|
|Keywords:||Exaptation; long terminal repeat; repetitive elements; retrotransposon; retrovirus|
|Rights:||© 2014 Stichting International Foundation for Animal Genetics|
|Appears in Collections:||Genetics publications|
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