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Type: Journal article
Title: Discovery of a novel long terminal repeat (LTR2i-SS) in Sus Scrofa
Author: Lim, S.
Kortschak, R.
Adelson, D.
Citation: Animal Genetics, 2014; 45(3):367-372
Publisher: Wiley
Issue Date: 2014
ISSN: 0268-9146
Statement of
Sim L. Lim, R. Daniel Kortschak and David L. Adelson
Abstract: Long terminal repeat (LTR) retrotransposons are transposable elements flanked by 5'/3' LTRs. They have a structure similar to endogenous retroviruses, but they lack the envelope (env) gene making them non-infectious. Long terminal repeats are motif-rich sequences and can act as bidirectional promoters or enhancers to regulate or inactivate genes by insertion. In this study, we identified a new chimeric LTR subfamily, LTR2i_SS, in the pig genome. This chimeric LTR family appears to be the ancestral form of the previously described LTR2_SS family. LTR2_SS appears to have deleted ~300 bp of un-annotated, ancestral sequence from LTR2i_SS. We identified no functional provirus sequences for either of these LTR types. LTR2i_SS sequences have been exapted into the untranslated regions of two protein-coding gene mRNAs. Both of these genes lie within previously mapped pig quantitative trait loci.
Keywords: Exaptation; long terminal repeat; repetitive elements; retrotransposon; retrovirus
Rights: © 2014 Stichting International Foundation for Animal Genetics
RMID: 0030008837
DOI: 10.1111/age.12138
Appears in Collections:Genetics publications

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