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Type: Journal article
Title: Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16
Author: Cavanaugh, J.
Callen, D.
Wilson, S.
Stanford, P.
Sraml, M.
Gorska, M.
Crawford, J.
Whitmore, S.
Shlegel, C.
Foote, S.
Kohonen-Corish, M.
Pavli, P.
Citation: Annals of Human Genetics, 1998; 62(4):291-298
Publisher: WILEY
Issue Date: 1998
ISSN: 0003-4800
Abstract: A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.
Keywords: Chromosomes, Human, Pair 16; Humans; Inflammatory Bowel Diseases; Crohn Disease; Genetic Predisposition to Disease; Chromosome Mapping; Pedigree; Genotype; Haplotypes; Lod Score; Australia; Female; Male; Genetic Linkage
Rights: © 1998 University College London
RMID: 0030004347
DOI: 10.1046/j.1469-1809.1998.6240291.x
Appears in Collections:Genetics publications

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