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|Title:||Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16|
|Citation:||Annals of Human Genetics, 1998; 62(4):291-298|
|Abstract:||A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.|
|Keywords:||Chromosomes, Human, Pair 16; Humans; Inflammatory Bowel Diseases; Crohn Disease; Genetic Predisposition to Disease; Chromosome Mapping; Pedigree; Genotype; Haplotypes; Lod Score; Australia; Female; Male; Genetic Linkage|
|Rights:||© 1998 University College London|
|Appears in Collections:||Genetics publications|
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