Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11412
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Type: Journal article
Title: Rapid detection of euchromatin by Alu-PRINS: use in clinical cytogenetics
Author: Callen, D.
Yip, M.
Eyre, H.
Citation: Chromosome Research, 1997; 5(2):81-85
Publisher: RAPID SCIENCE PUBLISHERS
Issue Date: 1997
ISSN: 0967-3849
1573-6849
Abstract: Alu-PRINS was successful in providing positive identification of euchromatin when oligoprimers were used at either extremity of the consensus Alu sequence. This technique was sensitive, as shown by the ability to detect small regions of euchromatin translocated to the short arm of an acrocentric chromosome. Since the Alu-PRINS technique is rapid and relatively simple, it will be useful in the diagnostic cytogenetics laboratory for the assessment of aberrant short arms of acrocentric satellites. This technique was also useful in defining the structure of small accessory marker chromosomes.
Keywords: Centromere; Chromatin; Euchromatin; Humans; Chromosome Disorders; Chromosome Aberrations; DNA Primers; In Situ Hybridization, Fluorescence; Sensitivity and Specificity; Repetitive Sequences, Nucleic Acid; Infant; Infant, Newborn; Female; Male
RMID: 0030004331
DOI: 10.1023/A:1018457806004
Appears in Collections:Genetics publications

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