Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/114187
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Type: Journal article
Title: Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse
Author: Dunleavy, J.E.M.
Okuda, H.
O'Connor, A.E.
Merriner, D.J.
O'Donnell, L.
Jamsai, D.
Bergmann, M.
O'Bryan, M.K.
Citation: PLoS Genetics, 2017; 13(11):e1007078-1-e1007078-28
Publisher: Public Library of Science (PLoS)
Issue Date: 2017
ISSN: 1553-7390
1553-7404
Editor: Matzuk, M.M.
Statement of
Responsibility: 
Jessica E.M. Dunleavy, Hidenobu Okuda, Anne E. O'Connor, D. Jo Merriner, Liza O'Donnell, Duangporn Jamsai, Martin Bergmann, Moira K. O'Bryan
Abstract: The katanin microtubule-severing proteins are essential regulators of microtubule dynamics in a diverse range of species. Here we have defined critical roles for the poorly characterised katanin protein KATNAL2 in multiple aspects of spermatogenesis: the initiation of sperm tail growth from the basal body, sperm head shaping via the manchette, acrosome attachment, and ultimately sperm release. We present data suggesting that depending on context, KATNAL2 can partner with the regulatory protein KATNB1 or act autonomously. Moreover, our data indicate KATNAL2 may regulate δ- and ε-tubulin rather than classical α-β-tubulin microtubule polymers, suggesting the katanin family has a greater diversity of function than previously realised. Together with our previous research, showing the essential requirement of katanin proteins KATNAL1 and KATNB1 during spermatogenesis, our data supports the concept that in higher order species the presence of multiple katanins has allowed for subspecialisation of function within complex cellular settings such as the seminiferous epithelium.
Keywords: Spermatids; sperm; germ cells; microtubules; centrioles; immunohistochemistry techniques; sperm head; spermatogenesis
Rights: © 2017 Dunleavy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pgen.1007078
Grant ID: http://purl.org/au-research/grants/arc/DP160100647
http://purl.org/au-research/grants/nhmrc/1058356
Published version: http://dx.doi.org/10.1371/journal.pgen.1007078
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