Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11425
Type: Journal article
Title: A very high density microsatellite map (1 STR/41kb) of 1.7 Mb on Xp22 spanning the microphthalmia with linear skin defects (MLS) syndrome critical region
Author: Cox, Timothy C.
Cox, Liza L.
Ballabio, Andrea
Citation: European Journal of Human Genetics, 1998; 6(4):406-412
Issue Date: 1998
ISSN: 1018-4813
Statement of
Responsibility: 
Timothy C Cox, Liza L Cox & Andrea Ballabio
Abstract: Microphthalmia with linear skin defects (MLS) syndrome is an X-linked disorder presenting only in XX individuals. It is characterised by dysmorphic features such as microphthalmia, sclerocornea, and linear streaks of erythematous and hypoplastic skin restricted to the head and neck. Karyotype analyses have so far revealed a terminal deletion or translocation causing monosomy for the distal Xp region (Xp22.3) in all patients. We have used existing cosmid clones from the region to perform a saturation screen for AC-type microsatellites with the goal of facilitating analysis of five novel patients with features of MLS. Three of these cases had an Xp22.3 abnormality, while the other two showed some characteristic features of MLS but had apparently normal karyotypes. Forty-two novel microsatellite markers have now been developed from the 1.7 Mb cloned interval. Ninety-three percent of the novel markers exhibited allelic variation, representing an average of one polymorphic PCR-based marker (STR) every 41 kb.
Keywords: Xp22; microsatellites; MLS; Aicard syndrome; Goltz syndrome; X chromosome; contiguous gene syndrome; microphthalmia; linear skin; focal dermal hypoplasia; paraffin-embedded
Appears in Collections:Genetics publications

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