Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114306
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dc.contributor.authorRichards, R.en
dc.contributor.authorRobertson, S.en
dc.contributor.authorKastner, D.en
dc.date.issued2018en
dc.identifier.citationHuman Molecular Genetics, 2018; 27(R2):108-118en
dc.identifier.issn0964-6906en
dc.identifier.issn1460-2083en
dc.identifier.urihttp://hdl.handle.net/2440/114306-
dc.description.abstractThe notion that one common pathogenic pathway could account for the various clinically distinguishable, typically late-onset neurodegenerative diseases might appear unlikely given the plethora of diverse primary causes of neurodegeneration. On the contrary, an autoinflammatory pathogenic mechanism allows diverse genetic and environmental factors to converge into a common chain of causality. Inflammation has long been known to correlate with neurodegeneration. Until recently this relationship was seen as one of consequence rather than cause - with inflammatory cells and events acting to "clean up the mess" after neurological injury. This explanation is demonstrably inadequate and it is now clear that inflammation is at the very least, rate-limiting for neurodegeneration (and more likely, a principal underlying cause in most if not all neurodegenerative diseases), protective in its initial acute phase, but pernicious in its latter chronic phase.en
dc.description.statementofresponsibilityRobert I. Richards, Sarah A. Robertson and Daniel L. Kastneren
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.comen
dc.titleNeurodegenerative diseases have genetic hallmarks of autoinflammatory diseaseen
dc.typeJournal articleen
dc.identifier.rmid0030085953en
dc.identifier.doi10.1093/hmg/ddy139en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1069348en
dc.identifier.pubid406528-
pubs.library.collectionMedical Sciences publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medical Sciences publications

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