Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11446
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Type: Journal article
Title: The identification and localisation of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster
Author: Coulson, M.
Robert, S.
Eyre, H.
Saint, R.
Citation: Genomics, 1998; 48(3):381-383
Publisher: ACADEMIC PRESS INC
Issue Date: 1998
ISSN: 0888-7543
1089-8646
Statement of
Responsibility: 
Michelle Coulson, Stanley Robert, Helen J Eyre, Robert Saint
Abstract: The Drosophila Polycomb group (PcG) of genes is required for the epigenetic regulation of a number of important developmental genes, including the homeotic (Hox) genes. The members of this gene family encode proteins that do not share sequence similarity, implying that each plays a unique role in this epigenetic repression mechanism. Polycomblike (Pcl) was the second PcG gene to be identified. We report here the isolation and characterization of a human cDNA, termed PHF1, which encodes a protein with significant sequence similarity to Drosophila Polycomblike (PCL). The region of similarity between PHF1 and PCL includes the two PHD fingers (C4-H-C3 motif), the region between them, and sequences C-terminal to the PHD fingers. PHF1 and PCL are 34% identical over this 258-residue region. PHF1 was mapped to 6p21.3 by fluorescence in situ hybridization. While several genetic diseases that are likely to result from developmental abnormalities map to this region, PHF1 is not a clear candidate gene for any of them.
Keywords: Chromosomes, Human, Pair 6; Animals; Humans; Mice; Drosophila melanogaster; Proteins; DNA-Binding Proteins; Drosophila Proteins; Transcription Factors; Repressor Proteins; DNA, Complementary; Sequence Alignment; Amino Acid Sequence; Sequence Homology, Amino Acid; Molecular Sequence Data; Polycomb-Group Proteins
RMID: 0030004306
DOI: 10.1006/geno.1997.5201
Appears in Collections:Genetics publications

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