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|Title:||Chromosomal localisation of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family|
|Citation:||Genomics, 1997; 44(1):127-130|
|Gino R. Somers, Fleur Hammet, Erica Woollatt, Robert I. Richards, Melissa C. Southey and Deon J. Venter|
|Abstract:||The G-protein-coupled P2Y purinoceptors mediate a variety of physiological effects in response to extracellular nucleotides. With the recent discovery of several new members from a variety of species, the P2Y purinoceptor family now encompasses types P2Y1to P2Y8. By fluorescencein situhybridization and utilization of the National Center for Biotechnology Information (NCBI) database, the human P2Y6gene was localized to chromosome 11q13.5, between polymorphic markers D11S1314 and D11S916. NCBI database analysis of the remaining human P2Y purinoceptor genes revealed that P2Y2and P2Y6mapped to within less than 4 cM, and thus constitute the first described chromosomal clustering of this gene family. Phylogenetic analysis of the P2Y purinoceptor family demonstrated the presence of five evolutionary branches and suggests the occurrence of an ancient gene duplication event.|
|Keywords:||Chromosomes, Human, Pair 11; Humans; Receptors, Purinergic P2; Genetic Markers; In Situ Hybridization, Fluorescence; Chromosome Mapping; Evolution, Molecular; Phylogeny; Metaphase; Multigene Family; Molecular Sequence Data; Male|
|Description:||Available online 18 April 2002|
|Rights:||Copyright © 1997 Academic Press. All rights reserved.|
|Appears in Collections:||Genetics publications|
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