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https://hdl.handle.net/2440/114721
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dc.contributor.author | Liu, X. | - |
dc.contributor.author | Sun, B. | - |
dc.contributor.author | Kell, R. | - |
dc.contributor.author | Southam, H. | - |
dc.contributor.author | Butler, J. | - |
dc.contributor.author | Li, X. | - |
dc.contributor.author | Poole, R. | - |
dc.contributor.author | Keene, F. | - |
dc.contributor.author | Collins, J. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | ChemPlusChem, 2018; 83(7):643-650 | - |
dc.identifier.issn | 2192-6506 | - |
dc.identifier.issn | 2192-6506 | - |
dc.identifier.uri | http://hdl.handle.net/2440/114721 | - |
dc.description | In memory of Leone Spiccia. This article is part of the Leone Spiccia Memorial Issue. To view the complete issue, visit: https://doi.org/10.1002/cplu.v83.7. Version of record online: April 20, 2018. | - |
dc.description.abstract | The cis‐α isomer of [Ru(bb₇)(dppz)]²⁺ (dppz=dipyrido[3,2‐a:2′,3′‐c]phenazine; bb7=bis[4(4′‐methyl‐2,2′‐bipyridyl)]‐1,7‐alkane) has been synthesised. The minimum inhibitory concentrations and the minimum bactericidal concentrations of [Ru(bb₇)(dppz)]²⁺ and its parent complex [Ru(phen)₂(dppz)]²⁺ (phen=1,10‐phenanthroline) were determined against a range of bacteria. The results showed that both ruthenium complexes exhibited good activity against Gram‐positive bacteria, but [Ru(bb₇)(dppz)]²⁺ showed at least eightfold better activity against the Gram‐negative bacteria than [Ru(phen)₂(dppz)]²⁺. Luminescence assays demonstrated that [Ru(bb₇)(dppz)]²⁺ accumulated in a Gram‐negative bacterium to the same degree as in a Gram‐positive species, and assays with liposomes showed that [Ru(bb₇)(dppz)]²⁺ interacted more strongly with membranes than the parent [Ru(phen)₂(dppz)]²⁺ complex. The DNA binding affinity for [Ru(bb₇)(dppz)]²⁺ was determined to be 6.7 × 10⁶ m⁻¹. Although more toxic to eukaryotic cells than [Ru(phen)₂(dppz)]²⁺, [Ru(bb₇)(dppz)]²⁺ exhibited greater activity against bacteria than eukaryotic cells. | - |
dc.description.statementofresponsibility | Xuewen Liu, Biyun Sun, Ruby E. M. Kell, Hannah M. Southam, Jonathan A. Butler, Xin Li, Robert K. Poole, F. Richard Keene, and J. Grant Collins | - |
dc.language.iso | en | - |
dc.publisher | Wiley-VCH Verlag | - |
dc.rights | © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.source.uri | http://dx.doi.org/10.1002/cplu.201800042 | - |
dc.subject | DNA binding | - |
dc.subject | antimicrobial agents | - |
dc.subject | bioinorganic chemistry | - |
dc.subject | lipophilicity | - |
dc.subject | ruthenium | - |
dc.title | The antimicrobial activity of mononuclear ruthenium(II) complexes containing the dppz ligand | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/cplu.201800042 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Keene, F. [0000-0001-7759-0465] | - |
Appears in Collections: | Aurora harvest 3 Chemistry publications |
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