Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114847
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFenwick, E.en
dc.contributor.authorXie, J.en
dc.contributor.authorRatcliffe, J.en
dc.contributor.authorPesudovs, K.en
dc.contributor.authorFinger, R.en
dc.contributor.authorWong, T.en
dc.contributor.authorLamoureux, E.en
dc.date.issued2012en
dc.identifier.citationInvestigative Ophthalmology and Visual Science, 2012; 53(2):677-684en
dc.identifier.issn0146-0404en
dc.identifier.issn1552-5783en
dc.identifier.urihttp://hdl.handle.net/2440/114847-
dc.description.abstractPURPOSE: To assess the impact of diabetic retinopathy (DR) and diabetic macular edema (DME) on health-related quality of life (HRQoL) in type 1 and type 2 diabetes using the EuroQoL EQ-5D generic multi-attribute utility instrument (MAUI). METHODS: In this cross-sectional study, 577 patients with diabetes were recruited from specialized eye clinics in Melbourne, Australia. Each patient underwent clinical, biochemical, and anthropometric assessments. The severity of combined DR and DME (no DR/DME; mild NPDR [nonproliferative DR (NPDR)] and/or mild DME; moderate NPDR and/or moderate DME; and vision-threatening DR (VTDR) (severe NPDR or PDR and/or severe DME) in the worse eye was calculated. EQ-5D utility measures were the main outcome. Because the distribution of the utility measures was skewed, independent associations were explored using multivariate quantile regression models (five quintiles, namely 15th, 30th, 45th, 60th, 75th) ranging from poorest to highest HRQoL. RESULTS: Median age of the participants was 66 years (range, 26-90 years). Of the 577 participants, 223 (38.7%) had no DR/DME, 35 (6.1%) had mild NPDR/DME, 127 (22.0%) had moderate NPDR/DME, and 192 (33.3%) had VTDR. In adjusted models, neither presence nor severity of DR/DME was significantly associated with any quantile of the EQ-5D. In contrast, the presence of diabetic complications (other than DR) (β = -0.153; SE = 0.052; P < 0.001), other nonocular comorbidities (β = -0.115; SE = 0.038; P < 0.01), and higher body mass index (β = -0.007; SE = 0.002; P < 0.001) were all associated with worse HRQoL. CONCLUSIONS: Using a generic MAUI, the EQ-5D, the authors found that the presence or severity of DR/DME and concomitant vision loss were not associated with any quantile of HRQoL. These findings suggest that the EQ-5D lacks sensitivity in assessing the impact of the severity of DR/DME on HRQoL parameters and that condition-specific instruments may better capture the full impact of the association.en
dc.description.statementofresponsibilityEva K. Fenwick, Jing Xie, Julie Ratcliffe, Konrad Pesudovs, Robert P. Finger, Tien Y. Wong, and Ecosse L. Lamoureuxen
dc.language.isoenen
dc.publisherAssociation for Research in Vision and Ophthalmologyen
dc.rightsCopyright 2012 The Association for Research in Vision and Ophthalmology, Inc.en
dc.subjectDiabetic Retinopathyen
dc.titleThe impact of diabetic retinopathy and diabetic macular edema on health-related quality of life in type 1 and type 2 diabetesen
dc.typeJournal articleen
dc.identifier.rmid0030098618en
dc.identifier.doi10.1167/iovs.11-8992en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/529923en
dc.relation.granthttp://purl.org/au-research/grants/arc/LP0884108en
dc.identifier.pubid176005-
pubs.library.collectionPublic Health publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRatcliffe, J. [0000-0001-7365-1988]en
Appears in Collections:Public Health publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.