Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11490
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Type: Journal article
Title: Febrile seizures and generalised epilepsy associated with a mutation in the Na+-channel b1 subunit gene SCN1B
Author: Wallace, R.
Wang, D.
Singh, R.
Scheffer, I.
George Jnr., A.
Phillips, H.
Saar, K.
Reis, A.
Johnson, E.
Sutherland, G.
Berkovic, S.
Mulley, J.
Citation: Nature Genetics, 1998; 19(4):366-370
Publisher: Nature
Issue Date: 1998
ISSN: 1061-4036
1546-1718
Statement of
Responsibility: 
Robyn H. Wallace, Dao W. Wang, Rita Singh, Ingrid E. Scheffer, Alfred L. George, Jr., Hilary A. Phillips, Kathrin Saar, Andre Reis, Eric W. Johnson, Grant R. Sutherland, Samuel F. Berkovic & John C. Mulley
Abstract: Febrile seizures affect approximately 3% of all children under six years of age and are by far the most common seizure disorder. A small proportion of children with febrile seizures later develop ongoing epilepsy with afebrile seizures. Segregation analysis suggests the majority of cases have complex inheritance but rare families show apparent autosomal dominant inheritance. Two putative loci have been mapped (FEB1 and FEB2), but specific genes have not yet been identified. We recently described a clinical subset, termed generalized epilepsy with febrile seizures plus (GEFS+), in which many family members have seizures with fever that may persist beyond six years of age or be associated with afebrile generalized seizures. We now report linkage, in another large GEFS+ family, to chromosome region 19q13.1 and identification of a mutation in the voltage-gated sodium (Na+)-channel beta1 subunit gene (SCN1B). The mutation changes a conserved cysteine residue disrupting a putative disulfide bridge which normally maintains an extracellular immunoglobulin-like fold. Co-expression of the mutant beta1 subunit with a brain Na+-channel alpha subunit in Xenopus laevis oocytes demonstrates that the mutation interferes with the ability of the subunit to modulate channel-gating kinetics consistent with a loss-of-function allele. This observation develops the theme that idiopathic epilepsies are a family of channelopathies and raises the possibility of involvement of other Na+-channel subunit genes in febrile seizures and generalized epilepsies with complex inheritance patterns.
Keywords: Oocytes; Chromosomes, Human, Pair 19; Animals; Xenopus laevis; Humans; Epilepsy, Generalized; Seizures, Febrile; Sodium Channels; Patch-Clamp Techniques; Pedigree; DNA Mutational Analysis; Amino Acid Sequence; Point Mutation; Molecular Sequence Data; Tasmania; Female; Male; Genetic Linkage
Description: Copyright © 1998 Nature America Inc.
RMID: 0030004275
DOI: 10.1038/1252
Appears in Collections:Genetics publications

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