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|Title:||Cell adhesion molecules are altered during irinotecan-induced mucositis: a qualitative histopathological study|
|Citation:||Supportive Care in Cancer, 2017; 25(2):391-398|
|Noor Al-Dasooqi, Joanne Bowen, Colin Bennett, John Finnie, Dorothy Keefe, Rachel Gibson|
|Abstract:||Purpose: Chemotherapy-induced mucositis is characterised by damage to mucous membranes throughout the alimentary tract. This study aims to investigate the expression of cell adhesion molecules (CAMs) following treatment with irinotecan. Methods: Dark agouti rats received a single dose of 175 mg/kg irinotecan and sacrificed at various time points after treatment. Picro-sirius red staining indicated an increase in collagen around crypts from 24 h in both small and large intestinal regions and this diminished at the later time points. CAMs E-cadherin, P-selectin, E-selectin and integrin-α1 were examined using immunohistochemistry. Results: E-cadherin was significantly elevated in jejunal crypts at the time of maximal tissue damage (48 h), while it decreased at the healing phase (96 h) in both jejunum and colon. P-selectin expression decreased significantly in the jejunum following irinotecan. Crypt expression of E-selectin was significantly elevated in the healing phase of mucositis (96 h). Integrin-α1 expression was significantly altered during the time course in the villus (p = 0.0032) and lamina propria (p = 0.039). Conclusions: Irinotecan induced a significant alteration in CAM expression in the jejunum and colon. Changes in adhesion molecule expression may have a direct impact on the loss of mucosal layer integrity seen in mucositis.|
|Keywords:||Alimentary tract; Chemotherapy; Adhesion proteins; Histopathology; Mucositis|
|Description:||Published online: 20 September 2016|
|Rights:||© Springer-Verlag Berlin Heidelberg 2016|
|Appears in Collections:||Medicine publications|
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