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https://hdl.handle.net/2440/115597
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Type: | Journal article |
Title: | Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood |
Author: | Wentworth, J.M. Bediaga, N.G. Penno, M.A. Bandala-Sanchez, E. Kanojia, K.N. Kouremenos, K.A. Couper, J.J. Harrison, L.C. ENDIA, S.G. |
Citation: | Metabolomics, 2018; 14(10):130-1-130-3 |
Publisher: | Springer US |
Issue Date: | 2018 |
ISSN: | 1573-3882 1573-3890 |
Statement of Responsibility: | John M. Wentworth, Naiara G. Bediaga, Megan A. S. Penno, Esther Bandala, Sanchez, Komal N. Kanojia, Konstantinos A. Kouremenos, Jennifer J. Couper, Leonard C. Harrison, ENDIA Study Group |
Abstract: | Background: Cord blood lipids are potential disease biomarkers. We aimed to determine if their concentrations were affected by delayed blood processing. Method: Refrigerated cord blood from six healthy newborns was centrifuged every 12 h for 4 days. Plasma lipids were analysed by liquid chromatography/mass spectroscopy. Results: Of 262 lipids identified, only eight varied significantly over time. These comprised three dihexosylceramides, two phosphatidylserines and two phosphatidylethanolamines whose relative concentrations increased and one sphingomyelin that decreased. Conclusion: Delay in separation of plasma from refrigerated cord blood has minimal effect overall on the plasma lipidome. |
Keywords: | Plasma lipidomics; cord blood; delayed processing; reproducibility; day-to-day variability |
Description: | Published online: 25 September 2018 |
Rights: | © Springer Science+Business Media, LLC, part of Springer Nature 2018 |
DOI: | 10.1007/s11306-018-1434-9 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1037321 http://purl.org/au-research/grants/nhmrc/1054618 http://purl.org/au-research/grants/nhmrc/1080887 |
Published version: | http://dx.doi.org/10.1007/s11306-018-1434-9 |
Appears in Collections: | Aurora harvest 3 Paediatrics publications |
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