Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/116057
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Sengupta, M. | - |
dc.contributor.author | Low, W. | - |
dc.contributor.author | Patterson, J. | - |
dc.contributor.author | Kim, H.-M. | - |
dc.contributor.author | Traven, A. | - |
dc.contributor.author | Beilharz, T. | - |
dc.contributor.author | Colaiacovo, M. | - |
dc.contributor.author | Schisa, J. | - |
dc.contributor.author | Boag, P. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Cell Science, 2013; 126(3):850-859 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.issn | 1477-9137 | - |
dc.identifier.uri | http://hdl.handle.net/2440/116057 | - |
dc.description.abstract | Large cytoplasmic ribonucleoprotein germ granule complexes are a common feature in germ cells. In C. elegans these are called P granules and for much of the life-cycle they associate with nuclear pore complexes in germ cells. P granules are rich in proteins that function in diverse RNA pathways. Here we report that the C. elegans homolog of the eIF4E-transporter IFET-1 is required for oogenesis but not spermatogenesis. We show that IFET-1 is required for translational repression of several maternal mRNAs in the distal gonad and functions in conjunction with the broad-scale translational regulators CGH-1, CAR-1 and PATR-1 to regulate germ cell sex determination. Furthermore we have found that IFET-1 localizes to P granules throughout the gonad and in the germ cell lineage in the embryo. Interestingly, IFET-1 is required for the normal ultrastructure of P granules and for the localization of CGH-1 and CAR-1 to P granules. Our findings suggest that IFET-1 is a key translational regulator and is required for normal P granule formation. | - |
dc.description.statementofresponsibility | Madhu S. Sengupta, Wai Yee Low, Joseph R. Patterson, Hyun-Min Kim, Ana Traven, Traude H. Beilharz, Monica P. Colaia, covo, Jennifer A. Schisa, and Peter R. Boag | - |
dc.language.iso | en | - |
dc.publisher | The Company of Biologists | - |
dc.rights | © 2013. Published by The Company of Biologists Ltd | - |
dc.source.uri | http://dx.doi.org/10.1242/jcs.119834 | - |
dc.subject | eIF4E transporter; P granule; germ granules; translational regulation; caenorhabditis elegans | - |
dc.title | ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1242/jcs.119834 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/606575 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Low, W. [0000-0002-0749-765X] | - |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 3 |
Files in This Item:
File | Description | Size | Format | |
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hdl_116057.pdf | Published version | 3.31 MB | Adobe PDF | View/Open |
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