Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/116060
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Type: Journal article
Title: Evolution of genes and genomes on the Drosophila phylogeny
Author: Clark, A.
Eisen, M.
Smith, D.
Bergman, C.
Oliver, B.
Markow, T.
Kaufman, T.
Kellis, M.
Gelbart, W.
Iyer, V.
Pollard, D.
Sackton, T.
Larracuente, A.
Singh, N.
Abad, J.
Abt, D.
Adryan, B.
Aguade, M.
Akashi, H.
Anderson, W.
et al.
Citation: Nature, 2007; 450(7167):203-218
Publisher: Nature Publishing Group
Issue Date: 2007
ISSN: 0028-0836
1476-4687
Statement of
Responsibility: 
Andrew G. Clark ... Lloyd Low ... et al.
Abstract: Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
Keywords: Drosophila Proteins; DNA Transposable Elements; RNA, Untranslated; Sequence Analysis, DNA; Genome, Insect; Genome, Mitochondrial
Rights: © 2007 Nature Publishing Group
RMID: 0030075964
DOI: 10.1038/nature06341
Appears in Collections:Animal and Veterinary Sciences publications

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