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https://hdl.handle.net/2440/11702
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Type: | Journal article |
Title: | Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig |
Author: | Sohlstrom, A. Katsman, A. Kind, K. Roberts, C. Owens, P. Robinson, J. Owens, J. |
Citation: | American Journal of Physiology: Endocrinology and Metabolism, 1998; 274(37):E410-E416 |
Publisher: | AMER PHYSIOLOGICAL SOC |
Issue Date: | 1998 |
ISSN: | 0193-1849 2163-5773 |
Abstract: | The effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through-4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother. |
Keywords: | Animals Guinea Pigs Weight Gain Insulin-Like Growth Factor I Insulin-Like Growth Factor II Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor Binding Protein 4 Food Deprivation Body Composition Embryonic and Fetal Development Pregnancy Placentation Pregnancy, Animal Female |
Rights: | © 1998 the American Physiological Society |
DOI: | 10.1152/ajpendo.1998.274.3.e410 |
Published version: | http://dx.doi.org/10.1152/ajpendo.1998.274.3.e410 |
Appears in Collections: | Aurora harvest 2 Physiology publications |
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